페이지 선택

HOME  abm  CRISPR CRISPR Activation Library

CRISPR Activation Library

CRISPR Activation (CRISPRa) allows you to selectively activate any gene by up to multiple thousand-fold. The key to CRISPRa is the dCas9-SAM complex, consisting of a catalytically-inactive Cas9 fused to a Synergistic Activation Mediator. The dCas9-SAM system can be targeted to the promoter of your gene of interest by expressing it in combination with specially-designed CRISPR Activation sgRNAs.

abm offers a complete collection of sgRNA-expressing CRISPR activation plasmids and viruses designed specifically for CRISPR Activation of any human, mouse, or rat gene. Our CRISPRa sgRNAs are available in lentivector or pre-packaged lentivirus for your convenience. Pair with our dCas9-SAM lentivector or dCas9-SAM lentivirus for the perfect CRISPR Activation experiment!

 

Key Features

  • Lentiviral delivery for integration of genetic material into host cells, leading to long term sgRNA expression.
  • Lentiviral vectors can be transfected for non-integrating, transient sgRNA expression.
  • A set of three sgRNA vectors/viruses is available for added assurance of efficient gene activation.

Looking for sgRNAs for other purposes (gene repression, epigenetic modification, etc.)? See our Custom CRISPR AAV Vectors and Viruses.

Popular Products

Additional Resources on CRISPR Technology

Top Publications

01

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.
Kang, Y J et al. Nat. Commun. 6:8371 (2015). DOI: 10.1038/ncomms9371.

 
02

Isorhapontigenin (ISO) inhibits invasive bladder cancer (BC) formation in vivo and human BC invasion in vitro by targeting STAT1/FOXO1 Axis. Jiang, G. et al. Cancer Prev Res. Published Online First April 14, 2016. doi: 10.1158/1940-6207.CAPR-15-0338

 
03 Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Okugawa, Y et al. Gut (2015) doi:10.1136/gutjnl-2015-309359

Browse Products

ZWS1 Activation CRISPR Vector/Virus
Sku: 6922712
Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZWS1 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZWS1 gene in CRISPRa applications.
ZWINTAS Activation CRISPR Vector/Virus
Sku: 6922612
Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZWINTAS gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZWINTAS gene in CRISPRa applications.
ZSCAN12L1 Activation CRISPR Vector/Virus
Sku: 6922212

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZSCAN12L1 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZSCAN12L1 gene in CRISPRa applications.
ZNF864P Activation CRISPR Vector/Virus
Sku: 6921012

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF864P gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF864P gene in CRISPRa applications.
ZNF850P Activation CRISPR Vector/Virus
Sku: 6920912

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF850P gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF850P gene in CRISPRa applications.
ZNF838 Activation CRISPR Vector/Virus
Sku: 6920812

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF850P gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF850P gene in CRISPRa applications.
ZNF834 Activation CRISPR Vector/Virus
Sku: 6920712

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF834 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF834 gene in CRISPRa applications.
ZNF833 Activation CRISPR Vector/Virus
Sku: 6920612

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF833 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF833 gene in CRISPRa applications.
ZNF828 Activation CRISPR Vector/Virus
Sku: 6920512

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF828 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF828 gene in CRISPRa applications.
ZNF826 Activation CRISPR Vector/Virus
Sku: 6920412

Unit: 1.0 μg per target, 300 μl
This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF826 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF826 gene in CRISPRa applications.

Page