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Drug Discovery Cell Lines

Leveraging abm’s proven success in the generation and validation of stable cell lines to accelerate your novel drug discoveries and biomedical research. Fully-validated, we have generated an unique library collection of G protein-coupled receptor (GPCR), Kinase, nuclear hormone receptor (NHR) and ion channel stable cell lines to provide powerful assay platforms for all research projects.

As a leader in gene expression and recombinant viral technology, we have streamlined the workflow from DNA construct cloning to recombinant viral vector generation and packaging, to gene expression quality control and to stable cell line generation for every gene in the human, mouse and rat genome. With our custom-tailored Whole-Genome Stable Cell Line solutions, the most difficult challenges in stable cell line creation can be overcome — so you can focus on answering the bigger questions in your project.

 

Product Information

Characterization of BRITER cell line

Characterization of BRITER cell line
Characterization of the BRITER Cell Line (T3105), which has a BMP Response Element-dependent Firefly Luciferase gene.

cell culture workflow

Cell Culture Workflow
The SUNE2 cell line is derived from a nasopharyngeal carcinoma (NPC) from the biopsy performed on a 38-year-old female Cantonese patient.

Custom Stable Cell Line Generation Workflow

Custom Stable Cell Line Generation Service
abm provides a high quality and a cost-effective service for creating a cell line expressing your gene of interest with a fast turnaround time.

Top PubliCations

01

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake in Prostate Cancer Mouse Xenografts.

Schlaepfer, I. R et al
Molecular Imaging and Biology 4:529-538 (2015).

DOI: 10.1007/s11307-014-0814-4.

02

Characterization of ryanodine receptor type 1 single channel activity using “on-nucleus” patch clamp.

Wagner, LE et al
Cell Calcium 56(2):96-107 (2014)

DOI: 10.1016/j.ceca.2014.05.004.

FAQs

  • Why do these cells need bio safety level II?

    In order to be more cautious, we follow the CDC-NIH recommendations that all mammalian sourced products should be handled at the Biological Safety Level 2 to minimize exposure of potentially infectious products. This information can be found in 'Biosafety in Microbiological and Biomedical Laboratories' (1999). Your institution's Safety Officer or Technical Services will be able to make the call as to whether BioSafety Level I is possible with these cells at your site if required.

  • How do you test for the presence of replication incompetent lentivirus in these cell line products?

    We perform this QC by testing viral titer of the culture media from each b atch using abm's qPCR titer kit (Cat# LV900), the results for which can be provided on the CoA for each lot#, upon request.

  • How long can I store frozen vials for?

    Cells that are properly frozen using an effective cryoprotective agent can be stored in liquid nitrogen indefinitely without affecting their recovery.