Coronavirus/SARS-CoV-2 Basics
We have the most comprehensive collection of coronavirus basic materials including genomic RNA, cDNA, different coronavirus proteins expressed in bacteria, baculouvirus, and 293 expression systems as well as antibodies for general coronavirus protein detection.
RNA and cDNA
abm provides RNA and DNA controls for quality control and validation of diagnostic tests.
| PRODUCT | DESCRIPTION |
|---|---|
| RNA Controls | Authentic coronavirus whole genome RNAs (30kb) isolated from clinical samples by heathcare professionals. |
| cDNA Controls | cDNAs reverse transcribed from coronavirus RNA using a mixture of random coronavirus specific primers. |
Protein
There are quite a few proteins that are known to be associated with coronavirus biology and we have prepared each of these proteins from different expression systems (bacteria, baculovirus, and 293 cells) in a ready-to-use format.
| PRODUCT | DESCRIPTION |
|---|---|
| Spike (S) | Mediates binding of SARS-CoV-2 to the ACE2 host cell receptor. |
| Nucleocapsid (N) | Binds and packs viral genome and regulates RNA synthesis during viral replication. |
| N-S fusion proteins | Fusion proteins. |
| Envelope (E) | Integral membrane protein that oligomerizes to form ion channels associated with SARS-CoV-2 pathogenesis. |
| Membrane (M) | Most abundant structural protein of SARS-CoV-2. Involved in organizing viral assembly. |
| ORF1ab | Encodes replicase polyproteins required for SARS-CoV-2 viral RNA replication and transcription. |
| RNA dependent RNA Polymerase (NSP12) | RNA replicase that catalyzes replication of RNA from an RNA template. |
| NSP1 | Nonstructural leader protein that inhibits translation of host mRNAs. |
| NSP15 | Nonstructural endoribonuclease protein important in viral infection and pathogenesis. |
| NSP7 | Nonstructural protein that forms a polymerization complex with nsp8 and nsp12. |
| NSP8 | Primase protein that forms a polymerization complex with nsp7 and nsp12. |
| NSP5A | Nonstructural protein. |
| NSP9 | Nonstructural RNA-binding protein that forms the replicase complex. |
| Papain-like Protease (PLpro) | Processes polyproteins into proteins for viral replication and removes ubiquitin and ISG15 from host proteins to inactivate the host immune response. |
| Guanine-N7 Methyltransferase Recombinant Protein (NSP14) | A proofreading exoribonuclease with a (guanine-N7) methyltransferase activity for viral mRNA capping. |
| Helicase (NSP13) | Unwinds double-stranded nucleic acid for viral self-reproduction. |
Antibodies
It will be impossible to advance coronavirus research without quality coronavirus antibodies. For this reason, we have developed coronavirus antibodies against different epitope proteins. In addition, we have also successfully isolated a collection of human coronavirus antibodies from convalescent coronavirus patients.
PRODUCT
| IMMUNOGEN | ||
|---|---|---|
| Spike (S) | Full length | View Products |
| S1 Subunit protein | View Products | |
| S2 Subunit | View Products | |
| Receptor Binding Domain (RBD) Subunit | View Products | |
| C-terminal | View Products | |
| Envelope (E) | Full length | View Products |
| N-terminal | View Products | |
| Nucleocapsid (N) | Full length | View Products |
| Membrane (M) | Full length | View Products |
| ORF1ab | Full length | View Products |
| RNA dependent RNA Polymerase (RDRP) | Full length | View Products |
| ORF7a | Full length | View Products |
| NSP8 | Full length | View Products |
| NSP3 | Full length | View Products |
| Helicase (NSP13) | Full length | View Products |
| 3CL Protease | Full length | View Products |
