Coronavirus/SARS-CoV-2 Receptors
Coronaviruses infect target cells by binding to receptors on the host cell membrane. For this reason, we offer a collection of receptor-related reagents, includes receptor expression vectors, proteins, antibodies, and stable cell lines. In addition, we also offer reagents for other host cell proteins involved in the SARS-CoV-2 infection mechanism.
Angiotensin Converting Enzyme 2 (ACE2)
The Angiotensin converting enzyme 2 (ACE2) is the host cell receptor for SARS-CoV-2 infections, binding to the Spike (S) protein on SARS-CoV-2.
| PRODUCT | DESCRIPTION |
|---|---|
| Gene Expression | ORF | Lenti- | Adeno- | AAV | Retro- | Protein Vector |
| Prottein Expression | Protein Lysate | Recombinant Protein |
| Antibodies | Monoclonal and Polyclonal |
| Cell Lines | – CRISPR ACE2 Knockout Cell Lines |
Transmembrane Serine Protease 2 (TMPRSS2)
Transmembrane Serine Protease 2 (TMPRSS2) facilitates fusion of SARS-CoV-2 with host cell membrane by cleaving and activating the viral spike glycoproteins.
| PRODUCT | DESCRIPTION |
|---|---|
| Gene Expression | ORF | Lenti- | Adeno- | AAV | Retro- | Protein Vector |
| Prottein Expression | Protein Lysate | Recombinant Protein |
| Antibodies | Monoclonal and Polyclonal |
| Cell Lines | CRISPR TMPRSS2 Knockout Cell Lines |
SARS-CoV-2 Spike Protein Pseudotype Lentivirus
Lentivirus products can be packaged with SARS-CoV-2 Spike protein instead of the standard vesicular stomatitis G (VSV-G) envelope glycoprotein to generate S protein pseudotype lentivirus, which can be used to study infection of cells expressing ACE2 (in vitro) or in animal models (in vivo). The Add-on option allows for any of abm’s cataloged or custom lentiviruses to be packaged with the S protein.
Other Related Host Cell Genes
For other Coronavirus related genes that are not listed in the table below, please inquire .
